Can Memotropil 1200 be used for open-angle glaucoma and which medications should be avoided with this disease?

Memotropil (piracetam) is not contraindicated for open-angle glaucoma, but it is advisable to consult your doctor before starting use.

With this form of glaucoma, mainly drugs that can increase intraocular pressure should be avoided:

Pseudoephedrine - is a sympathomimetic used in the symptomatic treatment of upper respiratory tract inflammation in the course of, m.in, cold, flu, allergic rhinitis. It is one of the ingredients of complex preparations (e.g. with paracetamol, ibuprofen), which patients often use for flu symptoms.

It can increase intraocular pressure, which in turn can lead to an acute glaucoma attack. Pseudoephedrine, which acts on receptors in the drainage angle, which consequently leads to inhibition of the outflow of liquid, causing an increase in the volume of the liquid and an increase in intraocular pressure. This condition is manifested by pain in the eye, hardness of the eyeball, conjunctival congestion, blurred vision caused even by corneal swelling.

Phenylephrine - used as an emergency measure to alleviate the symptoms of nasal swelling occurring in colds, flu or allergic diseases of the upper respiratory tract. Phenylephrine, like pseudoephedrine, acts as an agonist on adrenergic receptors in the drainage angle, inhibiting the outflow of aqueous humor.

Diphenhydramine - belonging to the first generation antihistamines, is available without a prescription in combination preparations (with paracetamol) and drugs used to alleviate sleep disorders. By acting as an anticholinergic, it makes it easier to fall asleep and calms down.
In addition, it causes pupil dilation, which can lead to a narrowing of the drainage angle and thus increase intraocular pressure. In addition, diphenhydramine can cause a decrease in tear production and worsen dry eye syndrome. Clemastine, an antihistamine from the same group of drugs, is also contraindicated in people with glaucoma or elevated intraocular pressure.

Corticosteroids - long-term use of this type of drugs can cause secondary, iatrogenic glaucoma. This condition is called pokortison glaucoma. Taking corticosteroids (e.g. hydrocortisone) in patients with glaucoma may lead to deterioration of vision. Corticosteroids are widely used in everyday clinical practice, e.g. they are often used chronically in bronchial asthma.

Anticholinergics - a group of drugs widely used in m.in. asthma (ipratropium), spasms of the gastrointestinal tract (scopolamine), diseases of the nervous system. This can trigger glaucoma in people with narrow angles of the anterior chamber by dilating the pupil and causing a pupil lock. When using this group of drugs, blurred vision and accommodation paralysis also occur.

Anxiolytics and antidepressants - before starting treatment, the patient should be tested for ophthalmological diseases. Antidepressants often cause reduced tear production and can cause a number of changes in the eyeball.

Studies have shown that TLPDs (tricyclic antidepressants, e.g. doxepin, amitriptyline), used as anxiolytics and sedatives, in high doses can cause paralysis of the eye muscles and an acute glaucoma attack. In people suffering from glaucoma, it is important to have regular ophthalmological examinations, as the risk of aggravating the disease with the use of TLPD is higher.

Selective serotonin uptake inhibitors (SSRIs) (e.g. citalopram, sertraline) can dilate the pupils, thereby narrowing the drainage angle and causing an increase in intraocular pressure. Venlafaxine, which acts as a serotonin and norepinephrine reuptake inhibitor (SNRI), is also an antidepressant. In this case, pupil dilation and an increase in intraocular pressure may also occur. Monitoring of patients at increased risk of glaucoma is recommended. The same is true for duloxetine.

Anxiolytic benzodiazepines (e.g. diazepam, lorazepam) should be used with caution in patients with glaucoma. They are not recommended for use in patients with untreated or incorrectly treated open-angle glaucoma.

I have attached additional information that may be helpful:

https://www.gdziepolek.pl/artykuly/leki-na-jaskre

https://www.gdziepolek.pl/artykuly/czy-mozna-wyleczyc-jaskre

If you need more personalized advice, you can use teleconsultations here:

https://www.gdziepolek.pl/telekonsultacja/

The availability of Memotropil in pharmacies in Polish can be checked at the following address:

https://www.gdziepolek.pl/produkty/48161/memotropil-tabletki-powlekane/apteki