Should I be concerned about the side effects of Duloxetine if my reaction to Paroxetine was very strong (after taking 5 mg I had symptoms that my doctor thought occur with an overdose and was advised to stop immediately)?

Duloxetine belongs to the group of serotonin-norepinephrine reuptake inhibitors (SNRIs). Paroxetine and Escitalopram - SSRIs. It is difficult to predict the body's reaction to a drug on the basis of an individual reaction to another medicinal substance, but - taking into account previous experience - all antidepressants should certainly be introduced very gradually.

I don't really understand. Escitalopram is an SSRI. Switching to Duloxetine should not be a problem in this case. However, if you are switching from Paroxetine to Duloxetine, it is a different story, because a different group of drugs and should take a break.