What is the difference between Fluoxetine and Doxepina? Is it possible to combine these drugs?

The drugs Fluoxetine and Doxepine belong to the group of antidepressants. Antidepressants are a very heterogeneous group. It includes substances that differ in chemical structure, action, application, as well as side effects. And this is also the case here. Fluoxetine is a new generation drug - it acts selectively on the level of serotonin (the so-called happiness hormone) in the human body. It is used in depressive, obsessive-compulsive disorders and bulimia. You can read more about fluoxetine here: https://www.gdziepolek.pl/substancje/fluoksetyna Doxepina is an older generation drug, it does not act so selectively (specifically at one point) of the body. Unlike drugs with fluoxetine, they affect not only serotonin (they act, for example, on muscarinic and histamine receptors), which increases the number of side effects resulting from their use. More about the drug: https://www.gdziepolek.pl/produkty/24749/doxepin-teva-kapsulki/apteki The doctor decides on the basis of the symptoms of the disease, constantly used drugs or other contraindications which drugs the patient should use, whether it should be a first or second generation drug. There is no such thing as an ideal antidepressant. The combination of fluoxetine and doxepine has therapeutic benefits, however, it is necessary to be careful when determining the doses of drugs (which only a doctor does). Most often, with the introduction of the second drug, the dose of the first is reduced. Combination therapy requires regular monitoring of potential side effects (m.in dry mouth, excessive drowsiness, confusion). Such symptoms may appear at a later time, so it is worth being aware of this and possibly reporting them to the doctor.