Methocarbamol may enhance the calming and sedative effects of antidepressants and anxiolytics. Caution should be exercised, especially at the beginning of treatment.

Information contained in the summary of product characteristics:

"The sedative effect of methocarbamol is enhanced by alcohol and central nervous system depressants (some antihistamines, sedatives, antidepressants, neuroleptics, opioid analgesics), which can lead to increased drowsiness or coma. Methocarbamol may potentiate the effects of appetite suppressants and anticholinergics."

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